TY - JOUR ID - 14807 TI - The Effects of ICD-85 in vivo and in vitro in Treatment of Cancer JO - Asia Pacific Journal of Medical Toxicology JA - APJMT LA - en SN - 2322-2611 AU - Zinatizadeh, Mohammad Reza AU - Zare Mirakabadi, Abbas AU - Kheirandish Zarandi, Peyman AU - Mirzaei, Hamid Reza AU - Parnak, Farzaneh AU - Javadi, Sholeh AD - Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran AD - 2. Department of Venomous Animal and Antivenom Production, Razi Vaccine and Serum Research Institute, Agriculture Research Education and Extension Organization (AREEO), Karaj, Iran AD - Cancer Research Center, Shohadae Tajrish Hospital, Department of Radiation Oncology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Biology, Sirjan Branch, Islamic Azad University, Sirjan, Iran AD - Department of Venomous Animal and Antivenom Production, Razi Vaccine and Serum Research Institute, Agriculture Research Education and Extension Organization (AREEO), Karaj, Iran Y1 - 2019 PY - 2019 VL - 8 IS - 4 SP - 130 EP - 135 KW - Breast Cancer KW - Gloydius Halys KW - Hemiscorpius lepturus KW - ICD-85 DO - 10.22038/apjmt.2019.14807 N2 - Background: Breast cancer is now the most important type of cancer in women around the globe and accounts for 25% of all types of cancer. Prevention and treatment of cancer are essential.Method: The main methods for treating cancer include chemotherapy, surgery, radiotherapy, gene therapy, and hormone therapy. Chemopreventive test programmes began in 1987, when over 1,000 agents and agent combinations were selected and evaluated in preclinical studies of chemopreventive activity against various types of cancers.Results: An important feature of anticancer drugs is a cytotoxic effect on cancer cells; these drugs have some cytotoxic agents found in animal venom. The ICD-85 is a combination of three peptides, ranging from 10,000 to 30,000 Da, and derived from the venom of the Iranian brown snake (Gloydius halys) and the yellow scorpion (Hemiscorpius lepturus).Conclusion: ICD-85 has an anti-proliferative effect and anti-angiogenesis activity on cancer cells. The side effects of chemotherapy are multiple drug resistance and effects on natural tissues, among others. Therefore, cytotoxic anticancer drugs are useful in treating cancer. The present work investigates the effects of ICD-85 on in vivo and in vitro studies. UR - https://apjmt.mums.ac.ir/article_14807.html L1 - https://apjmt.mums.ac.ir/article_14807_88471eda67f38531026daa6b6ea28bb2.pdf ER -