Epidemics of methanol poisoning happen across the globe. There are prognostic factors associated with morbidity or mortality from methanol poisoning. Recently we have compared retrospective observational case series of methanol-poisoned patients from Norway (1979 and 2002-2005), Estonia (2001) and Tunisia (2003/2004), and patients from two different centers in Iran (Teheran 2004-2009 and Mashhad 2009-2010).1 According to this findings, 23% died. Among them, a pH < 7.00, Glasgow Coma Scale (GCS) < 8, and a pCO2 ≥ 3.1 kPa in spite of a pH < 7.00 were found to be the strongest risk factor for poor outcome.
In Iran, methanol poisoning outbreaks happen on yearly basis. It is important to have a treatment protocol in place to be prepared for potential large ones, such as what has happened in Rafsanjan last year. This review emphasizes on a road map to develop a national guideline to encounter methanol poisoning/outbreaks.