1Gibb Epidemiology Consulting LLC, Arlington, VA, USA
2Department of Virology, Parasitology and Immunology, Ghent University, Merelbeke, Belgium
3Institute of Health and Society (IRSS), Université catholique de Louvain, Brussels, Belgium
4Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
5Emerging Pathogens Institute and Animal Sciences Department, University of Florida, Gainesville, FL, USA
6Exponent, Center for Chemical Regulation and Food Safety, Washington, DC, USA
7Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, USA
8Department of Agricultural, Food, and Resource Economics, Michigan State University, East Lansing, MI, USA
9National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands
10Faculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique
11Department of Food Safety and Zoonoses, World Health Organization, Geneva, Switzerland
12CSIRO Food and Nutrition Flagship, North Ryde, Australia
13Food Data Analysis Section, Food Standards Australia New Zealand, Canberra, Australia
14Department of Food Technology, University of Ibadan, Ibadan, Nigeria
15Environmental Health Services, British Columbia Centre for Disease Control, Vancouver, BC, Canada
16INTERTEK, Oak Brook, IL, USA
17Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands
18Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA
All people need food. Unsafe foods; however, may cause diseases ranging from diarrhea to cancer. Chemicals in food are a worldwide health concern. In 2006, the World Health Organization (WHO) organized a consultation on the global burden of foodborne diseases. Work to estimate this burden began in 2007 and was carried out by the WHO Foodborne Disease Burden Epidemiology Reference Group (FERG), which included a Chemical and Toxins Disease Task Force. The results of 8 years of work were released in December 2015.
How to cite this article: Gibb H, Devleesschauwer B, Bolger PM, Wu F, Ezendam J, Cliff J, et al. Asian Implications of Aflatoxin and Dioxin Foodborne Chemical Exposures Based on World Health Organization Estimates. Asia Pac J Med Toxicol 2015;4:131-3.
All people need food. Unsafe foods; however, may cause diseases ranging from diarrhea to cancer (1). Chemicals in food are a worldwide health concern (2). In 2006, the World Health Organization (WHO) organized a consultation on the global burden of foodborne diseases. Work to estimate this burden began in 2007 and was carried out by the WHO Foodborne Disease Burden Epidemiology Reference Group (FERG), which included a Chemical and Toxins Disease Task Force (3). The results of 8 years of work were released in December 2015 (4,5).
Chemicals in food are an important but poorly recognized health problem in developing countries, including Asian countries, where rapid industrialization and weak law enforcement mechanisms can lead to widespread environmental hazards. Asian countries in the FERG report are presented as East Mediterranean (EMR), South East Asian (SEAR) and Western Pacific (WPR) regions (Figure 1) (6).
Figure 1. The World Health Organization regions [image on the internet]. Available from: http://www.who.int/about/regions/en/
FERG estimated that four chemicals in food (aflatoxin, dioxin, cyanide in cassava and peanut allergens) led to 339,000 illnesses, 20,000 deaths and 1,012,000 DALYs globally in 2010 (4). Aflatoxin and dioxin exposures in Asian regions are described in the FERG report (4,5). Almost all human exposure to dioxin is through food (meat, dairy products, fish and shellfish). All human exposure to aflatoxin is through the food supply.
Aflatoxins occur naturally in some foods, particularly maize, peanuts, tree nuts and some oilseeds as secondary metabolites of specific Aspergillus species, as well as hydroxylation products found in milk and milk products (7,8). Health effects related to aflatoxin include frequently fatal hepatocellular carcinoma (HCC) (5). Hepatitis B is prevalent in Asian countries (9). Hepatitis B and aflatoxin exposure have a synergistic effect on development of HCC (10). Vaccination against hepatitis B may lead to extra benefits from a toxicological point of view. In Asia, aflatoxin exposure was disproportionately high in the WPR, which includes China, resulting in a median death rate of 0.5 (0.09-2) per 100,000 inhabitants, followed by the SEAR and EMR (Figure 2).
Dioxins (including dioxin like polychlorinated biphenyls) are products of industrial activities and natural sources including volcanic eruptions and forest fires. Dioxin accumulates in the body fat and may cause oligospermia and lead to impaired fertility in a subset of the population (5). Health risks associated with dioxin were highest in SEAR, followed by the EMR and WPR regions. Dioxin causes illnesses but not death (Figure 2). In general, among these three regions, EMR was found to experience the least effect from foodborne dioxin and aflatoxin.
Figure 2. Median rate per 100,000 foodborne illnesses, deaths, and DALYs by Asian related WHO regions (A) Aflatoxin and (B) Dioxin -- EMR: East Mediterranean Region, SEAR: South East Asian Region, WPR: West Pacific Region
In comparison with European and American regions, Asian countries have a higher risk of adverse health effects from aflatoxin and dioxin. Thus, an urgent need exists for increased scrutiny of chemicals in foods in Asia. This fact should be taken into account in policy making and budget allocations in these countries. Health policies with respect to food should be individually customized for Asian countries, as health data for many Asian countries are unavailable or incomplete (11).
Aflatoxin and dioxin health risks are the result of long-term exposure. This provides health authorities with the opportunity for interventions and health advice at the population level. For example, when exported foods such as pistachios are rejected by industrialized countries because of excessive chemical contamination, they may be redistributed in the country of origin. This practice should be stopped and all stocks of rejected food should be destroyed. Greater attention should be given to controlling exposure to aflatoxin and dioxin. In addition, from a health risk perspective, physicians should be notified of potential risks and endpoints for chemical exposure including screening biomarkers such as hemochromatosis for early diagnosis. As a long-term goal, more actions directed towards improved practices during production and storage are needed to make the food supply safer. Dietary advice for aflatoxin exposure include the risks related to consuming high volumes of contaminated nuts; awareness on high alcohol consumption; non-alcoholic fatty liver due to obesity and diabetes; and potential risks of concurrent iron overload (12). Dietary advice is more important for HBV-infected cases.
For dioxin, monitoring for concurrent drug use, alcohol use, occupation (welding or prolonged sitting such as truck driving), tobacco smoking, emotional stress and obesity could be more important for the subpopulation with low sperm counts (13).
The FERG paper addressed only four chemicals (4); however, other chemicals in food including arsenic, lead, cadmium and methyl mercury also need to be addressed in Asian countries (14).
Conflict of interest: HJG, BD, MPB, AHH, JB, PV, JIP, GA, RA, and DCB serve as members of the WHO Foodborne Disease Burden Epidemiology Reference Group without remuneration. DCB is a member of the WHO Expert Advisory Panel on Food Safety. All authors declare no competing interests.
World Health Organization. Food Safety; All people need food, each and every day [Internet]. 2015 [Cited 8 Dec 2015]. Available from: http://www.who.int/foodsafety/en/
World health organization. Food Safety; Chemical Risks [Internet]. 2015 [Cited 8 Dec 2015]. Available from: http://www.who.int/foodsafety/areas_work/chemical-risks/en/
World Health Organization (WHO). Department of Food Safety, Zoonoses and Foodborne Diseases Sustainable Development and Healthy Environments. WHO Consultation to Develop a Strategy to Estimate the Global Burden of Foodborne Diseases. Taking Stock and Charting the Way Forward. Geneva, Switzerland: WHO Press; 2007.
Gibb H, Devleesschauwer B, Bolger PM, Wu F, Ezendam J, Cliff J, et al. World Health Organization estimates of the global and regional disease burden of four foodborne chemical toxins, 2010: a data synthesis [version 1; referees: 2 approved, 1 approved with reservations]. F1000Research 2015;4:1393.
World Health Organization. WHO estimates of the global burden of foodborne diseases: foodborne disease burden epidemiology reference group 2007-2015. Geneva, Switzerland: WHO Press; 2015.
World Health Organisation. WHO regional offices [Internet]. 2015 [Cited 8 Dec 2015]. Available from: http://www.who.int/about/regions/en/
Liu Y, Wu F. Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. Environ Health Perspect 2010;118:818-24.
Kana JR, Gnonlonfin BG, Harvey J, Wainaina J, Wanjuki I, Skilton RA, et al. Assessment of aflatoxin contamination of maize, peanut meal and poultry feed mixtures from different agroecological zones in Cameroon. Toxins (Basel) 2013;5:884-94.
Utsumi T, Lusida MI. Viral hepatitis and human immunodeficiency virus co-infections in Asia. World J Virol 2015;4:96-104.
Moudgil V, Redhu D, Dhanda S, Singh J. A review of molecular mechanisms in the development of hepatocellular carcinoma by aflatoxin and hepatitis B and C viruses. J Environ Pathol Toxicol Oncol 2013;32:165-75.
The World Bank. World Development Indicators 2008. Washington, USA: The World Bank Publications; 2008.
Engstrom PF, Sigurdson E, Evans AA, Pingpank JF. Primary neoplasms of the liver. In: Kufe DW, Pollock RE, Weichselbaum RR, Bast RC, Gansler TS, Holland JF, et al., editors. Holland-Frei Cancer Medicine. 6th ed. Hamilton (ON), Canada: BC Decker; 2003. p.1542-53.
Kogevinas M. Human health effects of dioxins: cancer, reproductive and endocrine system effects. Hum Reprod Update 2001;7:331-9.
Afshari R, Bellinger DC. Socially Responsive Toxicology; Looking outside the Windows of Medical Wards: A Tale of Lead Exposure. Asia Pac J Med Toxicol 2015;4:95-6.