Archaeologists, historians, and physicians have frequently looked at historical pieces (visual arts) and events and found evidence that allow them to make diagnoses under certain assumptions. The elements of an image or a sculpture in iconography provide valuable clues advantageous in numerous areas such as medical and psychological diagnoses [1, 2].
This article evaluates a pre-Columbian ceramic mask from the Olmec civilization (1500-400 BCE, south-central Mexico) discovered in 1955 by the famous archaeologist Matthew Williams Stirling (1896 - 1975 CE) . This hybrid deity mask is kept at the Museo Internazionale delle Ceramiche in Faenza, Italy (figure 1) . The mask is divided into two halves; a half jaguar head (left) and a half-human head with a scalp and nose that looks like a half hat and the stem of a (magic) mushroom containing psilocybin (right).
In non-medical literature, it is believed that these masks show early use of magic mushrooms in pre-Columbian ceremonial events and symbolize the transformation of an earthly creature using magic mushrooms in pre-Columbian times in Central America  Likewise, research on prehistoric rock art from the Tassili caves in southern Algeria and near Villar del Humo in Spain claims to represent species of (magic) mushrooms containing psilocybin and psilocin from 5,000 to 7,000 BCE [6, 7].
The consumers of magic mushrooms (Figure 2) experience feelings of relaxation, euphoria, visual disturbances, delusions, and hallucinations . These findings may have been attributed to supernatural sources, as the power of the "divine" was deeply rooted in pre-Columbian times. Besides the theory of celestial transformation, this mask could be evaluated from a medical (toxicological) and psychological point of view.
Two halves of this mask (earth jaguar and divine human) are iconographic compared in Table 1. It appears that the skull transforms from an anxious and greedy-looking jaguar head to a relaxed, regular human face that has a scalp resembling a mushroom cap, suggesting psychoactive effects.
The jaguar's ear is concrete, relatively small without a hole. The right ear is trumpet ears (horn-shaped) with a large hole which could symbolize the increased hearing ability that could perceive divine speech. The jaguar’s eye is just an empty hole and presumably blind. However, the celestial eye on the right is anatomically intact and perhaps able to see past the eyeless earth creature on the left.
A tightly closed mouth with the tongue inside and regular teeth on the divine side can be a sign of a calm and without hunger state, suggestive of euphoria and lack of appetite common in the consumption of stimulants. A typical nose is also compatible with the fact that olfactory hallucinations are very rare.
The International Classification of Diseases (ICD-10) defines the clinical manifestation of hallucination as false sensory perception in the absence of external stimuli , primarily auditory, visual, and tactile. The leading causes of hallucination are psychological disorders and structural, infectious, functional, metabolic, and toxic exposures, including the consumption of psychoactive mushrooms.
The ancient use of psilocybin-containing fungi, including Psilocybe caerulescens, Psilocybe cubensis, Conocybe cyanopus, Panaeolus foenisecii, Gymnopilus spectabilis, and Psathyrella foenisecii, is widely recognized in ceremonies, especially in Central America. The perceptual distortions induced by magic mushrooms in antiquity could have led to auditory and visual hallucinations with a feeling of depersonalization and separation from the environment and tachycardia, hypertension, tachypnea, hyperthermia, diaphoresis, and gastrointestinal problems .
The Mexican mask suggests the divine transformation of the human soul in a metaphorical sense, as archaeologists suggest. It could also provide supporting evidence on auditory and visual hallucinations using the [ritual] use of the magic mushroom. This motif is probably the first documentation of a drug-induced hallucination a few millennia before the phenomenon was scientifically explained.
We hope to persuade professional readers of health and medicine to begin researching and reporting the rich Persian iconographic figures attributed to health and medicine across the country.
This article has been developed on the basis of regular iconographic studies. Therefore, it is the subject of speculation and the interpretations and claims need to be taken into account with caution.
Conflict of interest
None to be declared.
Funding and support: None