Document Type : Original Article


1 Alborz University of Medical Science, Karaj, Iran

2 Medical Doctor, Alborz University of Medical Science Karaj, Iran

3 Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran

4 Non- communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran

5 Emergency Department, Alborz University of Medical Science, Karaj, Iran


Introduction: Methanol is the simplest yet toxic alcohol found in many households and industrial materials. Exposure to methanol can be hazardous, and if left untreated, can result in mortality or severe morbidity. Methanol poisoning is mostly accidental, but it can result in mortality and severe morbidity. Due to the high prevalence of ECG changes in patients with methanol poisoning, this study aimed to evaluate the relationship of these ECG changes with methanol poisoning in determining the prognosis of the patients.
Methods: This cross-sectional study was conducted on 114 patients with acute methanol poisoning at the Shahid Rajaei Hospital in Karaj, Alborz Province, Iran. Clinical, laboratory and ECG variables were evaluated. Furthermore, the gathered data were analyzed with SPSS software.
Results: 1.8% of patients had a PR interval of less than 121ms, and 3.5% had more than 200ms. Among various ECG changes, only PR intervals of more than were significantly associated with mortality. Patients with short QT intervals had the highest PCO2, PH, and HCO3. On the other hand, people with long QT had the lowest amount of PCO2, PH, and HCO3, which was statistically significant. Laboratory tests showed significant differences in serum potassium level and blood PH between died and survived patients.
Discussion and conclusion: In our study, the most common finding in ECG was sinus tachycardia, and short QT was the second most common finding, which is consistent with other studies. Our study found that in ECGs, only PR intervals more than 200 have a significant relationship with mortality, which supports previous studies. Finally, it was that mortality in patients with methanol poisoning is significantly associated with PR interval prolongation, acidosis, and hyperkalemia.


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