Document Type : Original Article
Authors
1 Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Medical Toxicology Research Center, Faculty of Medicine, Mashhad, University of Medical Sciences, Mashhad, Iran
3 Department of Social Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4 Department of Clinical Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Background: Due to the increasing consumption of bottled water in recent years, to ensure the safety, we aimed to evaluate the concentration of 6 toxic heavy metals, nitrate and nitrite components in the commonly sold bottled water in Mashhad, Iran.
Methods: The 11 best-selling bottled water brand in Mashhad were identified. Eight bottles from each brand were randomly collected and delivered at the same day to toxicology laboratory of Imam Reza Hospital and refrigerated at 4-6 °C. Spectrophotometry and atomic absorption spectrometry and were used to measure the nitrate, nitrite and heavy metals, respectively. The results were analyzed by SPSS version 16 and compared with the WHO and Australian guidelines. Also, the discrepancy between measured components and the depicted labels’ values were compared.
Results: The mean and SD of concentrations of the heavy metals in 11 brand were as below: lead 1.62±0.86 [µg/L], chromium 1.03±0.84 [µg/L], cadmium 0.17±0.07 [µg/L], mercury 3.86±1.57 [µg/L], arsenic 0.89±0.46 [µg/L], aluminum 6.56±4.54 [µg/L]. The mean and SD measured quantities of nitrate, nitrite and pH were 9.96±5.95 [mg/L], 0.01±0.03 [mg/L] and 7.92±5.95, respectively. There was a significant difference between the label values and the quantitative levels except for 3 brands, which was observed with a p value of 0.518 and 0.642 for nitrate level in N4 and N11 brands, as well as 0.681 for pH level in N7 brand. The measured values of heavy metals, nitrate and nitrite in all samples were within domestic, WHO and Australian limits, except for mercury in 9 samples which exceeded the Australian standard [less than 1 µg/L].
Conclusion: The heavy metals, nitrate and nitrite concentrations in all samples were within the domestic, WHO and Australian ranges, except for mercury in 9 samples that exceeded the Australian standard. There was a discrepancy between entries of the bottled labels and the measured quantities.
Keywords
Main Subjects
- Lyubomirova V, Mihaylova V, Djingova R. Chemical characterization of Bulgarian bottled mineral waters. Journal of Food Composition and Analysis. 2020 Oct 1;93:103595.
- World Health Organization. Guidelines for drinking-water quality. World Health Organization; 2002.
- Abdul Wahid N, Tan Foon Cheng P, Abustan I, Yen Nee G. Consumers’ choice of drinking water: Is it dependent upon perceived quality, convenience, price and attitude?. AIP Conf. Proc. 16 October 2017; 1892 (1): 160012. https://doi.org/10.1063/1.5005779
4.Viscusi WK, Huber J, Bell J. The private rationality of bottled water drinking. Contemporary Economic Policy. 2015 Jul;33(3):450-67.
- Pip E. Survey of bottled drinking water available in Manitoba, Canada. Environmental health perspectives. 2000 Sep;108(9):863-6.6.
- Balali-Mood M, Riahi-Zanjani B, Yousefzadeh H, Sadeghi M. Concentrations of mercury, lead, chromium, cadmium, arsenic and aluminum in irrigation water wells and wastewaters used for agriculture in Mashhad, northeastern Iran. International Journal of Occupational & Environmental Medicine. 2013 Apr 1;4(2).
- Kapaj S, Peterson H, Liber K, Bhattacharya P. Human health effects from chronic arsenic poisoning–a review. Journal of Environmental Science and Health, Part A. 2006 Oct 1;41(10):2399-428.
- Steinmaus C, Yuan Y, Bates MN, Smith AH. Case-control study of bladder cancer and drinking water arsenic in the western United States. American journal of epidemiology. 2003 Dec 15;158(12):1193-201.
- Luster MI, Simeonova PP. Arsenic and urinary bladder cell proliferation. Toxicology and applied pharmacology. 2004 Aug 1;198(3):419-23.
- Chiu HF, Ho SC, Yang CY. Lung cancer mortality reduction after installation of tap-water supply system in an arseniasis-endemic area in Southwestern Taiwan. Lung Cancer. 2004 Dec 1;46(3):265-70.
- Liao CM, Shen HH, Chen CL, Hsu LI, Lin TL, Chen SC, Chen CJ. Risk assessment of arsenic-induced internal cancer at long-term low dose exposure. Journal of Hazardous Materials. 2009 Jun 15;165(1-3):652-63.
- Tsai SY, Chou HY, The HW, Chen CM, Chen CJ. The effects of chronic arsenic exposure from drinking water on the neurobehavioral development in adolescence. Neurotoxicology. 2003 Aug 1;24(4-5):747-53.
- Rezende HC, Nascentes CC, Coelho NM. Cloud point extraction for determination of cadmium in soft drinks by thermospray flame furnace atomic absorption spectrometry. Microchemical Journal. 2011 Mar 1;97(2):118-21.
- Méndez JÁ, García JB, Crecente RM, Martín SG, Latorre CH. A new flow injection preconcentration method based on multiwalled carbon nanotubes for the ETA-AAS determination of Cd in urine. Talanta. 2011 Oct 15;85(5):2361-7.
- Verougstraete V, Lison D, Hotz P. Cadmium, lung and prostate cancer: a systematic review of recent epidemiological data. Journal of Toxicology and Environmental Health, Part B. 2003 Jan 1;6(3):227-56.
- Tortajada, C., Radcliffe, J.C. (2021). Potable Water Reuse in Australia. In: The Palgrave Handbook of Climate Resilient Societies. Palgrave Macmillan, Cham. https://doi.org/10.1007/978-3-030-32811-5_80-1
- Pillay AE, Yaghi B, Williams JR, Al-Kindy S. Mercury pollution from irrigation with treated sewage water (TSW). Journal of water and health. 2007 Jun 1;5(2):315-22.
- Bondy SC, Campbell A. Aluminum and neurodegenerative diseases. InAdvances in neurotoxicology 2017 Jan 1;1:131-156.
- Kawahara M. Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases. Journal of Alzheimer's disease. 2005 Jan 1;8(2):171-82.
- Fewtrell L. Drinking-water nitrate, methemoglobinemia, and global burden of disease: a discussion. Environmental health perspectives. 2004 Oct;112(14):1371-4.
- Pennington JA. Dietary exposure models for nitrates and nitrites. Food Control. 1998 Dec 1;9(6):385-95.
- Ning Y, Li J, Cai W, Shao X. Simultaneous determination of heavy metal ions in water using near-infrared spectroscopy with preconcentration by nano-hydroxyapatite. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2012 Oct 1;96:289-94.
- Todolí JL, Mermet JM. Sample introduction systems for the analysis of liquid microsamples by ICP-AES and ICP-MS. Spectrochimica Acta Part B: Atomic Spectroscopy. 2006 Mar 1;61(3):239-83.
- Cicchella D, Albanese S, De Vivo B, Dinelli E, Giaccio L, Lima A, Valera P. Trace elements and ions in Italian bottled mineral waters: Identification of anomalous values and human health related effects. Journal of Geochemical Exploration. 2010 Dec 1;107(3):336-49.
- Barroso MF, Ramos S, Oliva-Teles MT, Delerue-Matos C, Sales MG, Oliveira MB. Survey of trace elements (Al, As, Cd, Cr, Co, Hg, Mn, Ni, Pb, Se, and Si) in retail samples of flavoured and bottled waters. Food additives and contaminants: Part B. 2009 Nov 1;2(2):121-30.
- Ikem A, Odueyungbo S, Egiebor NO, Nyavor K. Chemical quality of bottled waters from three cities in eastern Alabama. Science of the total environment. 2002 Feb 21;285(1-3):165-75.
- Krachler M, Shotyk W. Trace and ultratrace metals in bottled waters: survey of sources worldwide and comparison with refillable metal bottles. Science of the total environment. 2009 Jan 15;407(3):1089-96.
- Bakırdere S, Yaroğlu T, Tırık N, Demiröz M, Fidan AK, Maruldalı O, Karaca A. Determination of As, Cd, and Pb in Tap Water and Bottled Water Samples by Using Optimized GFAAS System with Pd‐Mg and Ni as Matrix Modifiers. Journal of Spectroscopy. 2013;2013(1):824817.
- Espejo-Herrera N, Kogevinas M, Castano-Vinyals G, Aragonés N, Boldo E, Ardanaz E, Azpiroz L, Ulibarrena E, Tardón A, Molina AJ, López-Rojo C. Nitrate and trace elements in municipal and bottled water in Spain. Gaceta Sanitaria. 2013;27:156-60.
- Ristić M, Popović I, Pocajt V, Antanasijević D, Perić-Grujić A. Concentrations of selected trace elements in mineral and spring bottled waters on the Serbian market. Food Additives and Contaminants. 2011 Mar 1;4(1):6-14.
- Azlan A, Khoo HE, Idris MA, Ismail A, Razman MR. Evaluation of minerals content of drinking water in Malaysia. The Scientific World Journal. 2012;2012(1):403574.
- Güler C, Alpaslan M. Mineral content of 70 bottled water brands sold on the Turkish market: Assessment of their compliance with current regulations. Journal of Food composition and Analysis. 2009 Nov 1;22(7-8):728-37.
- E Yilkal, F Zewge, B S Chandravanshi. Assessment of the quality of bottled water marketed in Addis Ababa, Ethiopia. Bulletin of The Chemical Society of Ethiopia, (2019).;33(1):21-41. doi: 10.4314/BCSE.V33I1.3
- Ali MA, Elgerbi AM, Emhemmad EJ, Amhimmid WK. Assessment of Some Physico-chemical and Bacteriological Properties of Bottled Drinking Water in the Wadi Al-Shati Area Southern of Libya. Assessment. 2020 Dec;7(6):06-11.
- Astel A, Michalski R, Łyko A, Jabłońska-Czapla M, Bigus K, Szopa S, Kwiecińska A. Characterization of bottled mineral waters marketed in Poland using hierarchical cluster analysis. Journal of Geochemical Exploration. 2014 Aug 1;143:136-45.
- Daniele L, Cannatelli C, Buscher JT, Bonatici G. Chemical composition of Chilean bottled waters: Anomalous values and possible effects on human health. Science of the total environment. 2019 Nov 1;689:526-33.
- Naddeo V, Zarra T, Belgiorno V. A comparative approach to the variation of natural elements in Italian bottled waters according to the national and international standard limits. Journal of Food Composition and Analysis. 2008 Sep 1;21(6):505-14.
- Misund A, Frengstad B, Siewers U, Reimann C. Variation of 66 elements in European bottled mineral waters. Science of the Total Environment. 1999 Dec 15;243:21-41.
- Gautam B. Chemical evaluation of trace elements in bottled water. Journal of Healthcare Engineering. 2020;2020(1):8884700.
- Al Aamri ZM, Ali BH. Chemical composition of different brands of bottled drinking water sold in Oman as labelled by manufacturers. Asian Journal of Water, Environment and Pollution. 2017 Jan 1;14(4):1-7.
- Bertoldi D, Bontempo L, Larcher R, Nicolini G, Voerkelius S, Lorenz GD, Ueckermann H, Froeschl H, Baxter MJ, Hoogewerff J, Brereton P. Survey of the chemical composition of 571 European bottled mineral waters. Journal of food composition and analysis. 2011 May 1;24(3):376-85.
- Hadiani MR, Dezfooli-Manesh S, Shoeibi S, Ziarati P, Mousavi Khaneghah A. Trace elements and heavy metals in mineral and bottled drinking waters on the Iranian market. Food Additives & Contaminants: Part B. 2015 Jan 2;8(1):18-24.
- Salehi I, Ghiasi M, Rahmani AR, Sepehr MN, Kiamanesh M, Rafati L. Evaluation of microbial and physico-chemical quality of bottled water produced in Hamadan province of Iran. Journal of food quality and hazards control. 2014 Mar 10;1(1):21-4.
- Nalatambi S. Determination of metals in tap water using atomic absorption spectrometry: a case study in Bandar Sunway residential area. Sunway academic journal. 2009;6:33-46.
- Elhamili A, Abokhshim A, Elaroud K, Elbaruni S. Determination of Heavy Metals in Tap and Underground Water Using Atomic Absorption Spectrometry. Journal of Chemical and Pharmaceutical Research. 2016;8[10]:108-11.
- Nuhu Aliyu, Aminu & Gambo Idris, Miftahu. [2022]. Atomic Absorption Spectroscopy Analysis of heavy metals in water at Daura Gypsum mining site, Yobe state, Nigeria.
- G.E.M. Hall, A.I. MacLaurin, J.C. Pelchat, G. Gauthier, Comparison of the techniques of atomic absorption spectrometry and inductively coupled plasma mass spectrometry in the determination of Bi, Se and Te by hydride generation, Chemical Geology, Volume 137, Issues 1–2, 1997, Pages 79-89, ISSN 0009-2541, https://doi.org/10.1016/S0009-2541[96]00156-8.
- World Health Organization. Guidelines for drinking-water quality: incorporating the first and second addenda. World Health Organization; 2022 Mar 31.
- National Health and Medical Research Council, National Resource Management Ministerial Council. Australian drinking water guidelines 6. Canberra: Commonwealth of Australia; 2011 [cited 2015 Oct 23]. Available from: www.nhmrc.gov.au/_files_nhmrc/file/publications/nhmrc_ adwg_6_february_2016.pdf