Document Type : Original Article
Authors
1 Department of Forensic Medicine, School of Medicine, Arak University of Medical Sciences, Arak, Iran
2 Department of Pharmacology, School of Medicine, Arak University of Medical Sciences, Arak, Iran
3 Department of Medicine, Arak University of Medical Sciences, Arak, Iran
Abstract
Background: Childhood poisoning poses serious health risks and complications. Numerous studies have highlighted differing rates of pediatric poisoning. This study investigates the prevalence, causes, and contributing factors of poisoning among children during the period from 2022 to 2024.
Methods: This cross-sectional study involved 483 children aged 1–18 years diagnosed with poisoning in Amir Kabir Hospital in Arak between March 2022 and March 2024. Data were retrospectively gathered from patient medical records during the specified period. Information on demographic details, seasonality, type of exposure (intentional or accidental), and general categories of poisoning agents was collected and analyzed using SPSS version 26.
Results: The mean age was 7.78 ± 5.75 years. Girls were significantly older than boys (8.79 ± 5.82 vs. 6.62 ± 5.45 years; P = 0.0001). Poisoning peaked in winter (30.6%). Mean hospital stay was 1.72 ± 1.06 days. Pharmaceutical poisoning was the most common cause (43.1%). Neurological symptoms were the most frequent presentation (49.9%). Accidental poisoning accounted for 76.4% of cases, with significant gender differences (accidental: 51.8% in boys; intentional: 71.1% in girls; P < 0.01).
Conclusion: Pharmaceutical agents represented the leading cause of pediatric poisoning in this study. These findings underscore the importance of enhancing medication safety measures, enforcing stricter controls on drug accessibility, and implementing targeted prevention strategies, particularly for younger children and adolescents.
Keywords
Main Subjects
- Nigam SK, Wu W, Bush KT, Hoenig MP, Blantz RC, Bhatnagar V. Handling of drugs, metabolites, and uremic toxins by kidney proximal tubule drug transporters. Clinical journal of the American Society of Nephrology. 2015;10(11):2039-49.
- Lee J, Fan N-C, Yao T-C, Hsia S-H, Lee E-P, Huang J-L, Wu H-P. Clinical spectrum of acute poisoning in children admitted to the pediatric emergency department. Pediatrics & Neonatology. 2019;60(1):59-67.
- Karpushkina ES, Zhdanova OA, Batishcheva GA. Acute poisoning in children: Etiology, structure, treatment tactics and outcomes. Research Results in Pharmacology. 2022;8(3):71-80.
- Marcdante K, Kliegman RM, Jenson H, Behrman R. Essentials of pediatrics. Elsevier, Philadelphia. 2015;11(14):231.
- Grabska K, Pilarska I. Acute poisoning among children and adolescents: A narrative review. Medical Science Pulse. 2022;16(3):33-9.
- Alonge O, Hyder AA. Reducing the global burden of childhood unintentional injuries. Archives of disease in childhood. 2014;99(1):62-9.
- Akbarizadeh MR, Naderifar M, Abdollahimohammad A, Saravani K. The causes of poisoning in children under 14 years old referred to Amir al-Momenin Ali hospital, Zabol, Iran. Medical Science. 2019;23(98):488-91.
- Sleet DA. The global challenge of child injury prevention. MDPI; 2018. p. 1921.
- Gummin DD, Mowry JB, Beuhler MC, Spyker DA, Rivers LJ, Feldman R, et al. 2022 Annual report of the national poison data system®(NPDS) from America’s Poison Centers®: 40th annual report. Clinical Toxicology. 2023;61(10):717-939.
- Dai Q, Wang L, Gao X, Du D, Shuai P, Li L, Liu W. Clinical and epidemiological characteristics of acute poisoning in children in southwestern China: a review of 1755 cases from 2014 to 2020. International journal of general medicine. 2022:133-42.
- Zhang H, Huo Q, Jing R, Dong M. Clinical analysis of acute poisoning in children. BMC pediatrics. 2024;24(1):212.
- Mintegi S, Azkunaga B, Prego J, Qureshi N, Dalziel SR, Arana-Arri E, et al. International epidemiological differences in acute poisonings in pediatric emergency departments. Pediatric emergency care. 2019;35(1):50-7.
- Li H, Dodd-Butera T, Beaman ML, Pritty MB, Heitritter TE, Clark RF. Trends in childhood poison exposures and fatalities: a retrospective secondary data analysis of the 2009–2019 US National Poison Data System annual reports. Pediatric reports. 2021;13(4):613-23.
- Marano M, Rossi F, Ravà L, Khalil Ramla M, Pisani M, Bottari G, et al. Acute toxic exposures in children: analysis of a three year registry managed by a Pediatric poison control Center in Italy. Italian journal of pediatrics. 2021;47(1):125.
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