Why Do the Results of Studies on the Effectiveness of Pralidoxime for Treatment of Organophosphate Poisoning Vary?

Bhalla, Ashish; Singh, Surjit

doi:10.22038/apjmt.2015.5988

Why Do the Results of Studies on the Effectiveness of Pralidoxime for Treatment of Organophosphate Poisoning Vary?

Document Type : Review Article

Authors

Ashish Bhalla

Surjit Singh

Post graduate Institute of Medical Education and Research, Chandigarh, India

https://doi.org/10.22038/apjmt.2015.5988

Abstract

Organophosphate (OP) compounds are frequently used agorchemicals for deliberate self-harm in some parts of the world resulting in high mortality and morbidity. Pralidoxime (2PAM) is the most widely used and trialed oxime for treatment of OP poisoning. There have been variations over the results of trials using 2PAM for OP poisoning. 2PAM therapy has led to favorable outcomes in some studies, whereas it has been associated with unfavorable outcomes or without benefit in the others. Why 2PAM works in some trials and why it does not in the others, has been a key question for medical toxicologists with no definite answer. In this systematic review, we sought to investigate possibilities of the variations in the results of different studies conducted on the effectiveness of 2PAM therapy for OP poisoning and we tried to provide solutions for future studies.

Keywords

Comparative Effectiveness Research

Organophosphate Poisoning

Oximes

Pralidoxime Compounds

How to cite this article: Bhalla A, Singh S. Why Do the Results of Studies on the Effectiveness of Pralidoxime for Treatment of Organophosphate Poisoning Vary? Asia Pac J Med Toxicol 2015;4:116-22.